San Francisco 49ers vs Indianapolis Colts – Prediction


There are only three weeks left of the regular NFL season, and the race for a playoff spot is as intense as always. Week 15 ended with the Broncos and Rams securing their spots in the postseason. Week 16 will see more teams secure their place, and one of them could be the 49ers. The final game of week 16 is the 49ers @ the Colts. In their last game, the 49ers had a comfortable 37-24 win against the Titans to make it four wins in a row. This puts them at 10-4 for the season and 3rd in the NFC West. Currently sitting in 6th place in the NFC rankings and a 98% probability of making the playoffs. They will be looking to cement their place against the Colts and have an outside chance of going one better than they did in 2023 and winning the Super Bowl, and put the bad memories of their poor 2024 season well behind them.
| 📅 Dates | Monday 22nd December 2025 |
| ⏰ Time | 20:15 (Eastern Standard Time) |
| 🏟️ Stadium | Lucas Oil Stadium, Indianapolis, USA |
| 🏆 Tournament | NFL |
The Colts suffered a 4th straight defeat in week 15th, losing 18-16 in the final seconds to the Seahawks. The biggest story was Philip Rivers coming out of retirement to play his first game in 5 years. Although he managed a TD pass, it wasn’t a winning return as he had hoped. Despite taking a 16-15 lead late in the 4th quarter, the Seahawks kicked a late field goal to win 18-16. The Colts were 7-1 after week 8 and 8-2 after week 10, and looking like a sure thing for the playoffs. They have since slumped to 8-6 and are currently not in a playoff spot. Their season isn’t over yet, though they will need to win all remaining games to be in with a chance and hope that results elsewhere go their way.
What is the latest team news?
Before making our San Francisco 49ers vs Indianapolis Colts prediction, we shall take a look at the team news.
San Francisco 49ers – Can they make it five wins in a row
The 49ers suffered several injuries during their victory against the Titans. Offensive lineman Spencer Burford and Cornerback Chase Lucas both suffered early injuries but were able to return to the game. Defensive tackle Jordan Elliot was not so lucky and suffered a knee injury before kickoff and was ruled out of the game. Finally, Wide Receiver Ricky Pearsall sustained an ankle injury in the first play of the game. Although he was able to return, he was in pain. Burford and Lucas are expected to return, but the 49ers may need to make late calls on Elliot and Pearsall as they have yet to be cleared to play.
Indianapolis Colts – Can Rivers get a first win in five years?
Well, the big question is, will Phillip Rivers be the starting QB for the game? It is the most probable option. Daniel Jones is out for the season, and Anthony Richardson, although medically cleared, isn’t believed to be fully fit. Riley Leonard could make a return after suffering a knee injury in his first game against Jacksonville and missing the defeat to the Seahawks.
Where to watch San Francisco 49ers vs the Indianapolis Colts
So, where can you watch to see if our San Francisco 49ers vs Indianapolis Colts prediction is correct?
In all honesty, there is no easy answer to that question; it depends in which country you reside and what subscriptions you may already have. There are a few free channels which have deals to show a selected number of games each week, details of which channels are in the list below.
- Australia – Seven Network shows three games for free each week.
- Germany – RTL and Nitro show most games for free.
- New Zealand – TVNZ+ shows three games a week for free.
- France – M6 shows one game a week for free.
- Mexico – Azteca 7 shows selected games for free.
- Spain – Movistar shows selected games for free.
- United Kingdom – Channel 5 shows two games for free each week.
- USA – ESPN show several games as part of their standard package.
If you’re looking for more comprehensive coverage, you will need to pay for a subscription. Outside of the U.S., most people choose to subscribe to a Game Pass on DAZN. This is available worldwide ( except China and the U.S.) and covers all games.
Your final option is to find a San Francisco 49ers vs. Indianapolis Colts live stream. There are several bookmakers out there that live stream the NFL. Generally, however, you can’t just join and watch any game at the bookmaker. They tend to have rules such as you must have placed a wager on the game or another NFL game. Some may just require that you have deposited and placed a bet in the last 24 hours. Others just require you to have funds in your account. Below is not a complete list, but the sites below offer live streaming of the NFL
- Caesars Sportsbook
- Fanatics Sportsbook
- DraftKings
- Bet MGM
- Bet 365
Again, depending on your location, you may or may not have access to these sites.
Prediction for San Francisco 49ers vs the Indianapolis Colts
The 49ers start the match as firm favourites. This isn’t a surprise; they have won 6 of 8 away games this season, including the last three. This means the bookmakers are not offering much value on them to win. Handicap betting, however, does, I believe, offer more value. The 49ers are 5.5-point favourites to win the game. ( Meaning to win the bet, they would need to win by 6 points) They won last out against the Titans by 13 points, and 18, 11, and 19-point wins in the previous three games against the Cardinals, Panthers, and Browns. So, for that reason, we not only believe the 49ers will win but also cover the -5.5 handicap, so our San Francisco 49ers vs. Indianapolis Colts prediction is that the 49ers will win by at least 6 points and cover the -5.5 handicap.


